Vin Mariani (doped with cocaine) had the greatest popularity ...
among the crowned heads and popes
Vin Mariani was a tonic and patent medicine created about 1863 by Angelo Mariani. In 1863, Mariani started marketing a wine called Vin Tonique Mariani (à la Coca du Pérou) which was made from Bordeaux wine and coca leaves. Vin Mariani was very popular in its day, even among royalty such as Queen Victoria. Pope Leo XIII and later Pope Saint Pius X were both Vin Mariani drinkers. Pope Leo awarded a Vatican gold medal to the wine, and also appeared on a poster endorsing it.