Known maker of poisons in the Roman Empire of the first century was ...

Agrippina
Locusta
Massalina
Xanthippe
Locusta was a notorious maker of poisons in the 1st-century Roman Empire, active in the final two reigns of the Julio-Claudian dynasty. She supposedly took part in the assassinations of Claudius and Britannicus. She was a favourite of emperor Nero for several years. Following Nero's death, Locusta was executed by his successor, Galba
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