Which infectious agent causes diseases that are the most difficult to cure?

bacteria
virus
fungus
prion
All known prion diseases affect the structure of the brain or other neural tissue and all are currently untreatable and universally fatal. This includes bovine spongiform encephalopathy (BSE, also known as "mad cow disease") in cattle and Creutzfeldt–Jakob disease (CJD) in humans.
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Answers by country

bacteria
virus
fungus
prion
answers
flagItaly
10%
26%
0%
63%
38
flagPakistan
6%
23%
6%
62%
143
flagGreece
5%
31%
2%
60%
38
flagRepublic of Ireland
9%
26%
2%
59%
71
flagMalaysia
2%
34%
6%
58%
50
flagPoland
8%
28%
7%
55%
24648
flagAustralia
10%
28%
5%
54%
103
flagthe Netherlands
8%
28%
8%
52%
46
flagCanada
7%
36%
6%
50%
113
flagGermany
7%
36%
5%
48%
995
flagSwitzerland
6%
40%
6%
47%
114
flagthe United States
7%
38%
6%
46%
1132
flagAustria
9%
39%
4%
46%
171
flagIndia
4%
42%
7%
44%
1005
flagthe United Kingdom
5%
42%
6%
44%
435
flagNigeria
1%
51%
2%
43%
80
flagGhana
3%
46%
3%
43%
32
flagthe United Arab Emirates
13%
32%
10%
37%
37
flagSouth Africa
13%
36%
10%
36%
30
flagthe Philippines
13%
48%
5%
31%
122