Which infectious agent is the most resistant to sterilization?
bacteria
virus
fungi
prion
The smaller the agent, the more difficult it is to destroy it. Prions are quite resistant to proteases, heat, radiation, and formalin treatments. 134°C (274°F) for 18 minutes in a pressurized steam autoclave may not be enough to deactivate the agent of disease. Prions may last for decades in the environment.
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bacteria
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prion
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143

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27

38

20508

28

76

50

44

367

95

1022

34

25

33

921

38

117

81