Which of the following drugs have the opposite effect to the others?

Heroin
Cocaine
Mescaline
Amphetamine
Heroin is a depressant - introduces euphoric sedation (like other opiates, including opium). The other mentioned drugs are stimulant stimulants.
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Answers by country

Heroin
Cocaine
Mescaline
Amphetamine
answers
flagFrance
70%
20%
10%
0%
10
flagAustralia
64%
7%
7%
21%
14
flagPakistan
46%
20%
20%
6%
15
flagGreece
43%
6%
25%
25%
16
flagthe United Kingdom
42%
7%
27%
22%
40
flagthe United States
39%
17%
19%
24%
41
flagAustria
34%
12%
31%
21%
32
flagIndia
29%
25%
3%
40%
27
flagGermany
26%
21%
24%
27%
215
flagPoland
25%
11%
48%
14%
7621
flagSwitzerland
18%
18%
33%
29%
27