Which of the following drugs have the opposite effect to the others?

Heroin
Cocaine
Mescaline
Amphetamine
Heroin is a depressant - introduces euphoric sedation (like other opiates, including opium). The other mentioned drugs are stimulant stimulants.
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Answers by country

Heroin
Cocaine
Mescaline
Amphetamine
answers
flagAustria
66%
0%
25%
8%
12
flagAustralia
64%
7%
7%
21%
14
flagPakistan
46%
20%
20%
6%
15
flagGreece
40%
6%
26%
26%
15
flagthe United States
38%
15%
26%
19%
26
flagthe United Kingdom
35%
5%
35%
23%
17
flagIndia
34%
21%
4%
39%
23
flagGermany
26%
15%
25%
32%
78
flagPoland
24%
10%
49%
14%
7091
flagSwitzerland
20%
0%
46%
33%
15